研究業績

2024年

原著

• "Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer"
  Namkaew J, Zhang J, Yamakawa N, Hamada Y, Tsugawa K, Oyadomari M, Miyake M, Katagiri T, Oyadomari S.
  Cancer Lett 582, 216509 (2024).

  • DOI: 10.1016/j.canlet.2023.216509
• "Methylmercury-induced brain neuronal death in CHOP-knockout mice"
  Iijima Y, Miki R, Fujimura M, Oyadomari S, Uehara T.
  J Toxicol Sci. 49, 2, 55-60 (2024).

  • DOI: 10.2131/jts.49.55.
• "Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells. "
  Miwata T, Suga H, Mitsumoto K, Zhang J, Hamada Y, Sakakibara M, Soen M, Ozaki H, Asano T, Miyata T, Kawaguchi Y, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Oyadomari S, Arima H.
  Peptides 173, 171151 (2024).

  • DOI: 10.1016/j.peptides.2024.171151

2023年

原著

• "ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions"
  Tanaka T, Nguyen DT, Kwankaew N, Sumizono M, Shinoda R, Ishii H, Takarada-Iemata M, Hattori T, Oyadomari S, Kato N, Mori K, Hori O.
  Neurochemical Research 48, 2175-2186 (2023).

  • DOI: 10.1007/s11064-023-03900-4
• "Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development"
  Yoshinaga K, Yasue A, Mitsui SN, Minegishi Y, Oyadomari S, Imoto I, Tanaka E.
  Genes (Basel) 14, 340 (2023).

  • DOI: 10.3390/genes14020340

2022年

原著

• "Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo"
  Du Q, Wu J, Fischer C, Seki T, Jing X, Gao J, He X, Hosaka K, Tong L, Yasue A, Miyake M, Sobajima M, Oyadomari S, Sun X, Yang Y, Zhou Q, Ge M, Tao W, Yao S, Cao Y.
  Proceedings of the National Academy of Sciences of the United States of America 119, e2203307119 (2022).

  • DOI: 10.1073/pnas.2203307119
• "The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion"
  Sobajima M, Miyake M, Hamada Y, Tsugawa K, Oyadomari M, Inoue R, Shirakawa J, Arima H, Oyadomari S.
  Biochemical and Biophysical Research Communications 30, 165-171 (2022).

  • DOI: 10.1016/j.bbrc.2022.04.038
• "Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells."
  Miyake M, Sobajima M, Kurahashi K, Shigenaga A, Denda M, Otaka A, Saio T, Sakane N, Kosako H, Oyadomari S.
  Cell Chemical Biology 29, 996-1009 (2022).

  • DOI: 10.1016/j.chembiol.2022.01.002

2021年

原著

• "Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity."
  Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S.
  iScience 24, 103448 (2021).

  • DOI: 10.1016/j.isci.2021.103448
• "Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway."
  Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T, Shapiro AMJ, Chew RSE, Keong Teo AK, Oyadomari S, Terauchi Y, Shirakawa J.
  Diabetes 71, 424-439 (2021).

  • DOI: 10.2337/db21-0123
• "ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model."
  Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S.
  Molecular Metabolism 54, 101338 (2021).

  • DOI: 10.1016/j.molmet.2021.101338
• "Effective three-dimensional culture of hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells."
  Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Yamada S, Imura S, Miyake M, Morine Y, Oyadomari S, Shimada M.
  Journal of Hepato-Biliary-Pancreatic Sciences 28, 705-715 (2021).

  • DOI: 10.1002/jhbp.1024
• "The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity."
  Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O.
  Scientific Reports 11, 13086 (2021).

  • DOI: 10.1038/s41598-021-92529-w
• "A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition"
  Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, Masai H, Poellinger L, Kato H.
  Scientific Reports 11, 4538 (2021).

  • DOI: 10.1038/s41598-021-83857-y

2020年

原著

• "Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung."
  Habuta M, Yasue A, Suzuki KT, Fujita H, Sato K, Kono H, Takayama A, Bando T, Miyaishi S, Oyadomari S, Tanaka E, Ohuchi H.
  PLoS One 15, e0240333 (2020).

  • DOI: 10.1371/journal.pone.0240333
• "Dkk3/REIC, an N-glycosylated protein, is a physiological endoplasmic reticulum stress inducer in the mouse adrenal gland."
  Fujita H, Bando T, Oyadomari S, Ochiai K, Watanabe M, Kumon H, Ohuchi H.
  Acta Medica Okayama 74, 199-208 (2020).

  • DOI: 10.18926/AMO/59950
• "Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells."
  Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M, Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I.
  Blood Advances 4, 1845-1858 (2020).

  • DOI: 10.1182/bloodadvances.2019001139
• "The C-terminal region including the MH6 domain of Msx1 regulates skeletal development."
  Ichihara A, Yasue A, Mitsui SN, Arai D, Minegishi Y, Oyadomari S, Imoto I, Tanaka E.
  Biochemical and Biophysical Research Communications 526, 62-69 (2020).

  • DOI: 10.1016/j.bbrc.2020.03.068
• "Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation."
  Hamada Y, Furumoto Y, Izutani A, Taniuchi S, Miyake M, Oyadomari M, Teranishi K, Shimomura N, Oyadomari S.
  PLoS One 15, e0229948 (2020).

  • DOI: 10.1371/journal.pone.0229948
• "ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue."
  Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.
  Life Science Alliance 3, e201900576 (2020).

  • DOI: 10.26508/lsa.201900576

2019年

原著

• "Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation."
  Stevens AM, Xiang M, Heppler LN, To?i? I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA.
  Blood Advances 3, 4215-4227 (2019).

  • DOI: 10.1182/bloodadvances.2019000499
• "Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity."
  Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, Kojima H, Kosako H, Kuribara T, Yoshida S, Hosoya T, Oyadomari S.
  eLife 8, e43302 (2019).

  • DOI: 10.7554/eLife.43302
• "Metabolic and innate immune cues merge into a specific inflammatory response via the UPR."
  Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sall? D, Aksoy E, Staels B, Dombrowicz D.
  Cell 177, 1201-1216.e19 (2019).

  • DOI: 10.1016/j.cell.2019.03.018
• "Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes."
  Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K.
  International Journal of Molecular Sciences i 20, 1706 (2019).

  • DOI: 10.3390/ijms20071706

総説

• "小胞体でのタンパク質品質管理を標的とした創薬開発最前線"
  親泊政一
  腎臓内科・泌尿器科 10, 211-217 (2019).
• "小胞体ストレスとイムノメタボリズム"
  親泊政一
  The Lipid 30, 28-34 (2019).

2018年

原著

• "Activin E controls energy homeostasis in both brown and white adipose tissues as a hepatokine."
  Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.
  Cell Reports 25, 1193-1203 (2018).

  • DOI: 10.1016/j.celrep.2018.10.008
• "PERK-mediated translational control is required for collagen secretion in chondrocytes."
  Hisanaga S, Miyake M, Taniuchi S, Oyadomari M, Morimoto M, Sato R, Hirose J, Mizuta H, Oyadomari S.
  Scientific Reports 8, 773 (2018).

  • DOI: 10.1038/s41598-017-19052-9

総説

• "骨格筋におけるエネルギー代謝と小胞体ストレス"
  親泊政一
  THE BONE 32, 67-72 (2018).

2017年

原著

• "A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning."
  Fischer C, Seki T, Lim S, Nakamura M, Andersson P, Yang Y, Honek J, Wang Y, Gao Y, Chen F, Samani NJ, Zhang J, Miyake M, Oyadomari S, Yasue A, Li X, Zhang Y, Liu Y, Cao Y.
  nature communications 8, 2079 (2017).

  • DOI: 10.1038/s41467-017-02158-z
• "Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice."
  Miyake M, Kuroda M, Kiyonari H, Takehana K, Hisanaga S, Morimoto M, Zhang J, Oyadomari M, Sakaue H, Oyadomari S.
  PLoS One 12, e0179955 (2017).

  • DOI: 10.1371/journal.pone.0179955
• "The role of heparin cofactor ? in the regulation of insulin sensitivity and maintenance of glucose homeostasis in humans and mice."
  Kurahashi K, Inoue S, Yoshida S, Ikeda Y, Morimoto K, Uemoto R, Ishikawa K, Kondo T, Yuasa T, Endo I, Miyake M, Oyadomari S, Matsumoto T, Abe M, Sakaue H, Aihara KI.
  Journal of Atherosclerosis and Thrombosis 24, 1215-1230 (2017).

  • DOI: 10.5551/jat.37739
• "Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos."
  Yasue A, Kono H, Habuta M, Bando T, Sato K, Inoue J, Oyadomari S, Noji S, Tanaka E, Ohuchi H.
  Scientific Reports 7, 53 (2017).

  • DOI: 10.1038/s41598-017-00088-w
• "ER Stress protein CHOP mediates insulin resistance by modulating adipose tissue macrophage polarity."
  Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomari S, Katagiri H.
  Cell Reports 18, 2045-2057 (2017).

  • DOI: 10.1016/j.celrep.2017.01.076

総説

• "小胞体ストレスとインスリン抵抗性"
  親泊政一
  Diabetes Frontier 28, 575-580 (2017).

2016年

原著

• "Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development."
  Mitsui SN, Yasue A, Masuda K, Naruto T, Minegishi Y, Oyadomari S, Noji S, Imoto I, Tanaka E.
  Scientific Reports 6, 38398 (2016).

  • DOI: 10.1038/srep38398
• "Integrated stress response of vertebrates is regulated by four eIF2α kinases."
  Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S.
  Scientific Reports 6, 32886 (2016).

  • DOI: 10.1038/srep32886
• "Correction: Long-Term Low Carbohydrate Diet Leads to Deleterious Metabolic Manifestations in Diabetic Mice."
  Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H.
  PLoS One 11, e0155751 (2016).

  • DOI: 10.1371/journal.pone.0155751
• "Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice."
  Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H.
  Neuroscience Letters 612, 199-203 (2016).

  • DOI: 10.1016/j.neulet.2015.12.031
• "Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism."
  Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S.
  The FASEB Journal 30, 798-812 (2016).

  • DOI: 10.1096/fj.15-275990

総説

• "膵β細胞における脂肪毒性"
  The Lipid 特別企画 特集新しいリピドーシス 27, 66-72 (2016).

2015年

原著

• "A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet."
  Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.
  British Journal of Pharmacology 172, 4519-4534 (2015).

  • DOI: 10.1111/bph.13236
• "Gamma-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice."
  Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.
  Endocrinology 156, 1242-1250 (2015).

  • DOI: 10.1210/en.2014-1748
• "Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice."
  Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
  Hepatology 61, 1343-1356 (2015).

  • DOI: 10.1002/hep.27619
• "Palmitate-stimulated monocytes induce adhesion molecule expression in endothelial cells via IL-1 signaling pathway."
  Shikama Y, Aki N, Hata A, Nishimura M, Oyadomari S, Funaki M.
  Journal of Cellular Physiology 230, 732-742 (2015).

  • DOI: 10.1002/jcp.24797

2014年

原著

• "Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice."
  Azuma Y, Hagiwara D, Lu W, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H.
  Endocrinology 155, 4905-4914 (2014).

  • DOI: 10.1210/en.2014-1522
• "Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice."
  Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H.
  PLoS One 9, e104948 (2014).

  • DOI: 10.1371/journal.pone.0104948
• "Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems."
  Yasue A, Mitsui SN, Watanabe T, Sakuma T, Oyadomari S, Yamamoto T, Noji S, Mito T, Tanaka E.
  Scientific Reports 4, 5705 (2014).

  • DOI: 10.1038/srep05705
• "Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein."
  Uehara Y, Hirose J, Yamabe S, Okamoto N, Okada T, Oyadomari S, Mizuta H.
  Osteoarthritis and Cartilage 22, 1007-1017 (2014).

  • DOI: 10.1016/j.joca.2014.04.025

総説

• "代謝、がん、免疫におけるPERK経路の役割"
  親泊政一
  実験医学 32, 2226-2232 (2014).

2013年

原著

• "Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome."
  Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.
  Nature 499, 97-101 (2013).

  • DOI: 10.1038/nature12347

総説

• "マイオカインとしてのFGF21によるエネルギー代謝制御 (特集 インスリン感受性,エネルギー代謝の新規モディファイヤー)"
  親泊政一
  (2013).

2012年

原著

• "Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice."
  Kozuka C, Yabiku K, Sunagawa S, Ueda R, Taira SI, Ohshiro H, Ikema T, Yamakawa K, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, Masuzaki H.
  Diabetes 61, 3084-3093 (2012).

  • DOI: 10.2337/db11-1767
• "Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2α phosphorylation and 4E-BP1 dephosphorylation."
  Morotomi-Yano K, Oyadomari S, Akiyama H, Yano KI.
  Experimental Cell Research 318, 1733-1744 (2012).

  • DOI: 10.1016/j.yexcr.2012.04.016

総説

• "小胞体ストレスと糖尿病 (特集 臨床医にもわかる糖尿病基礎研究)"
  親泊政一
  ホルモンと臨床 60, 905-910 (2012).

2011年

原著

• "Influence of the hepatic eukaryotic initiation factor 2α (eIF2aα) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism."
  Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, Ron D, Samuel VT, Shulman GI.
  Journal of Biological Chemistry 286, 36163-36170 (2011).

  • DOI: 10.1074/jbc.M111.228817
• "Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses."
  Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H.
  Circulation 124, 830-839 (2011).

  • DOI: 10.1161/CIRCULATIONAHA.110.014050
• "CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse."
  Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nakamura H, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.
  Apoptosis 16, 438-448 (2011).

  • DOI: 10.1007/s10495-011-0576-2

総説

• "小胞体ストレスと生活習慣病"
  親泊政一
  医学のあゆみ 237, 714-719 (2011).
• "総論　解明が進む小胞体ストレスと疾患発症"
  親泊政一
  BIO Clinica 26, 16-27 (2011).

2010年

原著

• "Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress."
  Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K.
  Molecular Biology of the Cell 21, 2975-2986 (2010).

  • DOI: 10.1091/mbc.E09-02-0133

2009年

総説

• "小胞体:小胞体ストレスと糖尿病"
  親泊政一,
  Diabetes Frontier 20, 715-720 (2009).

2008年

原著

• "The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis."
  Ariyama Y, Tanaka Y, Shimizu H, Shimomura K, Okada S, Saito T, Yamada E, Oyadomari S, Mori M, Mori M.
  Metabolism 57, 1625-1635 (2008).

  • DOI: 10.1016/j.metabol.2008.06.019
• "Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3."
  Petrova K, Oyadomari S, Hendershot LM, Ron D.
  The EMBO Journal 27, 2862-2872 (2008).

  • DOI: 10.1038/emboj.2008.199
• "Dephosphorylation of translation initiation factor 2α enhances glucose tolerance and attenuates hepatosteatosis in mice."
  Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D.
  Cell Metabolism 7, 520-532 (2008).

  • DOI: 10.1016/j.cmet.2008.04.011

2007年

原著

• "Chop-deficient mice showed increased adiposity but no glucose intolerance."
  Ariyama Y, Shimizu H, Satoh T, Tsuchiya T, Okada S, Oyadomari S, Mori M, Mori M.
  Obesity 15, 1647-1656 (2007).

  • DOI: 10.1038/oby.2007.197

2006年

原著

• "Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload."
  Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D.
  Cell 126, 727-739 (2006).

  • DOI: 10.1016/j.cell.2006.06.051
• "NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153."
  Awai M, Koga T, Inomata Y, Oyadomari S, Gotoh T, Mori M, Tanihara H.
  Journal of Neurochemistry 96, 43-52 (2006).

  • DOI: 10.1111/j.1471-4159.2005.03502.x

2005年

原著

• "The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice."
  Endo M, Oyadomari S, Suga M, Mori M, Gotoh T.
  Journal of Biochemistry 138, 501-507 (2005).

  • DOI: 10.1093/jb/mvi143

総説

• "小胞体ストレスと膵β細胞障害"
  親泊政一
  先端医療シリーズ糖尿病の最新医療 32, 81-86 (2005).
• "糖尿病発症における小胞体ストレスの関与"
  親泊政一
  実験医学 23, 2778-2783 (2005).

2004年

原著

• "CHOP induces death by promoting protein synthesis and oxidation in the stressed endo-plasmic reticulum."
  Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D.
  Genes & development 18, 3066-3077 (2004).

  • DOI: 10.1101/gad.1250704
• "Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP."
  Tajiri S, Oyadomari Seiichi, Yano S, Morioka M, Gotoh T, Hamada I. J, Ushio Y, Mori M.
  Cell death and differentiation 11, 403-415 (2004).

  • DOI: 10.1038/sj.cdd.4401365
• "hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria."
  Gotoh T, Terada K, Oyadomari Seiichi, Mori M.
  Cell death and differentiation 11, 390-402 (2004).

  • DOI: 10.1038/sj.cdd.4401369
• "Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage."
  Lee KJ, Terada K, Oyadomari S, Inomata Y, Mori M, Gotoh T.
  Cell Stress Chaperones 9, 58-68 (2004).

  • DOI: 10.1379/459.1

総説

• "Lipid phase perturbations and the unfolded protein response."
  Ron D, Oyadomari S.
  Developmental cell 7, 287-288 (2004).

  • DOI: 10.1016/j.devcel.2004.08.011
• "Roles of CHOP/GADD153 in endoplasmic reticulum stress."
  Oyadomari Seiichi, Mori M.
  Cell death and differentiation 11, 381-389 (2004).

  • DOI: 10.1038/sj.cdd.4401373

2003年

原著

• "Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells."
  Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP, Ron D.
  The Journal of cell biology 163, 767-775 (2003).

  • DOI: 10.1083/jcb.200308075
• "Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung."
  Endo M, Oyadomari S, Terasaki Y, Takeya M, Suga M, Mori M, Gotoh T.
  American Journal of Physiology-Lung Cellular and Molecular Physiology 285, L313-321 (2003).

  • DOI: 10.1152/ajplung.00434.2002
• "Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cells."
  Koga T, Zhang WY, Gotoh T, Oyadomari S, Tanihara H, Mori M.
  Experimental eye research 76, 15-21 (2003).

  • DOI: 10.1016/s0014-4835(02)00274-9

総説

• "Impact of endoplasmic reticulum stress pathway on pancreatic β-cells and diabetes mellitus."
  Araki E, Oyadomari S, Mori M.
  Experimental biology and medicine 228, 1213-1217 (2003).

  • DOI: 10.1177/153537020322801018
• "糖尿病と小胞体ストレス"
  荒木 栄一、親泊政一、森正敬
  生化学 75, 1324-1331 (2003).
• "Endoplasmic reticulum stress and diabetes mellitus."
  Araki E, Oyadomari S, Mori M.
  Internal medicine 42, 44756 (2003).

  • DOI: 10.2169/internalmedicine.42.7
• "小胞体ストレスとβ細胞障害"
  親泊政一、荒木栄一、森正敬
  内分泌・糖尿病科 16, 38-46 (2003).
• "小胞体ストレスと糖尿病"
  親泊政一、荒木栄一、森正敬
  分子糖尿病学の進歩2003 3, 71-78 (2003).

2002年

原著

• "Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes."
  Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M.
  The Journal of Clinical Investigation 109, 525-532 (2002).

  • DOI: 10.1172/JCI14550
• "Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP."
  Gotoh T, Oyadomari S, Mori K, Mori M.
  The Journal of Biological Chemistry 277, 12343-12350 (2002).

  • DOI: 10.1074/jbc.M107988200

総説

• "Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells."
  Oyadomari S, Araki E, Mori M.
  Apoptosis 7, 335-345 (2002).

  • DOI: 10.1023/a:1016175429877
• "小胞体ストレスと疾患"
  親泊政一, 森正敬
  基礎老化研究 シンポジウム 26, 112-117 (2002).

2001年

原著

• "Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells."
  Kawahara K, Oyadomari S, Gotoh T, Kohsaka S, Nakayama H, Mori M.
  FEBS Letters 506, 135-139 (2001).

  • DOI: 10.1016/s0014-5793(01)02898-8
• "Nitric oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate."
  Kawahara K, Gotoh T, Oyadomari S, Kuniyasu A, Kohsaka S, Mori M, Nakayama H.
  Neuroscience Letters 310, 89-92 (2001).

  • DOI: 10.1016/s0304-3940(01)02079-1
• "Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway."
  Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E, Mori M.
  Proc Natl Acad Sci U S A 98, 10845-10850 (2001).

  • DOI: 10.1073/pnas.191207498
• "Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells."
  Kawahara K, Gotoh T, Oyadomari Seiichi, Kajizono M, Kuniyasu A, Ohsawa K, Imai Y, Kohsaka S, Nakayama H, Mori M.
  Molecular Brain Research 90, 165-173 (2001).

  • DOI: 10.1016/s0169-328x(01)00100-0
• "Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats."
  Oyadomari S, Gotoh T, Aoyagi K, Araki E, Shichiri M, Mori M.
  Nitric oxide 5, 252-260 (2001).

  • DOI: 10.1006/niox.2001.0344
• "CCAAT/enhancer-binding protein β is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes."
  Kimura T, Chowdhury S, Tanaka T, Shimizu A, Iwase K, Oyadomari S, Gotoh T, Matsuzaki H, Mori M, Akira S, Takiguchi M.
  FEBS Letters 494, 105-111 (2001).

  • DOI: 10.1016/s0014-5793(01)02320-1

2000年

原著

• "Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide."
  Zhang WY, Gotoh T, Oyadomari S, Mori M.
  Brain Res Mol Brain Res 83, 1-8 (2000).

  • DOI: 10.1016/s0169-328x(00)00154-6
• "The gene for hepatocyte nuclear factor (HNF)-4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver."
  Oyadomari S, Matsuno F, Chowdhury S, Kimura T, Iwase K, Araki E, Shichiri M, Mori M, Takiguchi M.
  FEBS Letters 478, 141-146 (2000).

  • DOI: 10.1016/s0014-5793(00)01840-8

1999年

総説

• "NO とアルギニン代謝のクロストーク"
  親泊政一, 森正敬
  羊土社 1, 28-35 (1999).