2024年
原著
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"Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells. "
Miwata T, Suga H, Mitsumoto K, Zhang J, Hamada Y, Sakakibara M, Soen M, Ozaki H, Asano T, Miyata T, Kawaguchi Y, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Oyadomari S, Arima H.
Peptides 173, 171151 (2024).
2023年
原著
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"ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions"
Tanaka T, Nguyen DT, Kwankaew N, Sumizono M, Shinoda R, Ishii H, Takarada-Iemata M, Hattori T, Oyadomari S, Kato N, Mori K, Hori O.
Neurochemical Research 48, 2175-2186 (2023).
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2022年
原著
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"Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo"
Du Q, Wu J, Fischer C, Seki T, Jing X, Gao J, He X, Hosaka K, Tong L, Yasue A, Miyake M, Sobajima M, Oyadomari S, Sun X, Yang Y, Zhou Q, Ge M, Tao W, Yao S, Cao Y.
Proceedings of the National Academy of Sciences of the United States of America 119, e2203307119 (2022).
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"Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells."
Miyake M, Sobajima M, Kurahashi K, Shigenaga A, Denda M, Otaka A, Saio T, Sakane N, Kosako H, Oyadomari S.
Cell Chemical Biology 29, 996-1009 (2022).
2021年
原著
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"Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity."
Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S.
iScience 24, 103448 (2021).
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"Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway."
Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T, Shapiro AMJ, Chew RSE, Keong Teo AK, Oyadomari S, Terauchi Y, Shirakawa J.
Diabetes 71, 424-439 (2021).
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"ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model."
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S.
Molecular Metabolism 54, 101338 (2021).
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"Effective three-dimensional culture of hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells."
Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Yamada S, Imura S, Miyake M, Morine Y, Oyadomari S, Shimada M.
Journal of Hepato-Biliary-Pancreatic Sciences 28, 705-715 (2021).
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"The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity."
Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O.
Scientific Reports 11, 13086 (2021).
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2020年
原著
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"Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung."
Habuta M, Yasue A, Suzuki KT, Fujita H, Sato K, Kono H, Takayama A, Bando T, Miyaishi S, Oyadomari S, Tanaka E, Ohuchi H.
PLoS One 15, e0240333 (2020).
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"Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells."
Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M, Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I.
Blood Advances 4, 1845-1858 (2020).
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"ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue."
Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.
Life Science Alliance 3, e201900576 (2020).
2019年
原著
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"Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation."
Stevens AM, Xiang M, Heppler LN, To?i? I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA.
Blood Advances 3, 4215-4227 (2019).
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"Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity."
Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, Kojima H, Kosako H, Kuribara T, Yoshida S, Hosoya T, Oyadomari S.
eLife 8, e43302 (2019).
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"Metabolic and innate immune cues merge into a specific inflammatory response via the UPR."
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sall? D, Aksoy E, Staels B, Dombrowicz D.
Cell 177, 1201-1216.e19 (2019).
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"Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes."
Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K.
International Journal of Molecular Sciences i 20, 1706 (2019).
総説
2018年
原著
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"Activin E controls energy homeostasis in both brown and white adipose tissues as a hepatokine."
Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.
Cell Reports 25, 1193-1203 (2018).
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総説
2017年
原著
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"A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning."
Fischer C, Seki T, Lim S, Nakamura M, Andersson P, Yang Y, Honek J, Wang Y, Gao Y, Chen F, Samani NJ, Zhang J, Miyake M, Oyadomari S, Yasue A, Li X, Zhang Y, Liu Y, Cao Y.
nature communications 8, 2079 (2017).
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"Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice."
Miyake M, Kuroda M, Kiyonari H, Takehana K, Hisanaga S, Morimoto M, Zhang J, Oyadomari M, Sakaue H, Oyadomari S.
PLoS One 12, e0179955 (2017).
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"The role of heparin cofactor ? in the regulation of insulin sensitivity and maintenance of glucose homeostasis in humans and mice."
Kurahashi K, Inoue S, Yoshida S, Ikeda Y, Morimoto K, Uemoto R, Ishikawa K, Kondo T, Yuasa T, Endo I, Miyake M, Oyadomari S, Matsumoto T, Abe M, Sakaue H, Aihara KI.
Journal of Atherosclerosis and Thrombosis 24, 1215-1230 (2017).
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"Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos."
Yasue A, Kono H, Habuta M, Bando T, Sato K, Inoue J, Oyadomari S, Noji S, Tanaka E, Ohuchi H.
Scientific Reports 7, 53 (2017).
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"ER Stress protein CHOP mediates insulin resistance by modulating adipose tissue macrophage polarity."
Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomari S, Katagiri H.
Cell Reports 18, 2045-2057 (2017).
総説
2016年
原著
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"Correction: Long-Term Low Carbohydrate Diet Leads to Deleterious Metabolic Manifestations in Diabetic Mice."
Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H.
PLoS One 11, e0155751 (2016).
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"Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice."
Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H.
Neuroscience Letters 612, 199-203 (2016).
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"Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism."
Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S.
The FASEB Journal 30, 798-812 (2016).
総説
2015年
原著
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"A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet."
Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.
British Journal of Pharmacology 172, 4519-4534 (2015).
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"Gamma-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice."
Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.
Endocrinology 156, 1242-1250 (2015).
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"Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice."
Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
Hepatology 61, 1343-1356 (2015).
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2014年
原著
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"Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice."
Azuma Y, Hagiwara D, Lu W, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H.
Endocrinology 155, 4905-4914 (2014).
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"Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice."
Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H.
PLoS One 9, e104948 (2014).
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総説
2013年
原著
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"Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome."
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.
Nature 499, 97-101 (2013).
総説
2012年
原著
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"Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice."
Kozuka C, Yabiku K, Sunagawa S, Ueda R, Taira SI, Ohshiro H, Ikema T, Yamakawa K, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, Masuzaki H.
Diabetes 61, 3084-3093 (2012).
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総説
2011年
原著
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"Influence of the hepatic eukaryotic initiation factor 2α (eIF2aα) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism."
Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, Ron D, Samuel VT, Shulman GI.
Journal of Biological Chemistry 286, 36163-36170 (2011).
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"Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses."
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H.
Circulation 124, 830-839 (2011).
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"CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse."
Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nakamura H, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.
Apoptosis 16, 438-448 (2011).
総説
2010年
原著
2009年
総説
2008年
原著
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"The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis."
Ariyama Y, Tanaka Y, Shimizu H, Shimomura K, Okada S, Saito T, Yamada E, Oyadomari S, Mori M, Mori M.
Metabolism 57, 1625-1635 (2008).
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2007年
原著
2006年
原著
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"Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload."
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D.
Cell 126, 727-739 (2006).
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2005年
原著
総説
2004年
原著
総説
2003年
原著
総説
2002年
原著
総説
2001年
原著
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"Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells."
Kawahara K, Gotoh T, Oyadomari Seiichi, Kajizono M, Kuniyasu A, Ohsawa K, Imai Y, Kohsaka S, Nakayama H, Mori M.
Molecular Brain Research 90, 165-173 (2001).
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"CCAAT/enhancer-binding protein β is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes."
Kimura T, Chowdhury S, Tanaka T, Shimizu A, Iwase K, Oyadomari S, Gotoh T, Matsuzaki H, Mori M, Akira S, Takiguchi M.
FEBS Letters 494, 105-111 (2001).
2000年
原著
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"The gene for hepatocyte nuclear factor (HNF)-4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver."
Oyadomari S, Matsuno F, Chowdhury S, Kimura T, Iwase K, Araki E, Shichiri M, Mori M, Takiguchi M.
FEBS Letters 478, 141-146 (2000).
1999年
総説