研究業績

2021年

原著

• "Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity."
  Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S.
  iScience 24, 103448 (2021).

  • DOI: 10.1016/j.isci.2021.103448
• "Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway."
  Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T, Shapiro AMJ, Chew RSE, Keong Teo AK, Oyadomari S, Terauchi Y, Shirakawa J.
  Diabetes 71, 424-439 (2021).

  • DOI: 10.2337/db21-0123
• "ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model."
  Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S.
  Molecular Metabolism 54, 101338 (2021).

  • DOI: 10.1016/j.molmet.2021.101338
• "Effective three-dimensional culture of hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells."
  Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Yamada S, Imura S, Miyake M, Morine Y, Oyadomari S, Shimada M.
  Journal of Hepato-Biliary-Pancreatic Sciences 28, 705-715 (2021).

  • DOI: 10.1002/jhbp.1024
• "The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity."
  Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O.
  Scientific Reports 11, 13086 (2021).

  • DOI: 10.1038/s41598-021-92529-w
• "A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition"
  Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, Masai H, Poellinger L, Kato H.
  Scientific Reports 11, 4538 (2021).

  • DOI: 10.1038/s41598-021-83857-y